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Friday, October 1, 2021
New “almanac” may help clinicians better tailor cancer treatments for patients
OCTOBER 1, 2021
New 'almanac' may help clinicians better tailor cancer treatments
by Allessandra Dicorato, Broad Institute of MIT and Harvard

Researchers have developed a tool that integrates a variety of molecular data from patients and tumors, with the goal of guiding precision medicine.


A promise of precision cancer medicine is for oncologists to tailor tre  ...more
Friday, October 1, 2021
Most cases of never-smokers' lung cancer treatable with mutation-targeting drugs
SEPTEMBER 30, 2021
by Julia Evangelou Strait, Washington University School of Medicine

A new study from Washington University School of Medicine in St. Louis estimates that 78% to 92% of lung cancers in patients who have never smoked can be treated with precision drugs already approved by the Food and Drug Administration to target specific mutations in a patient’s t  ...more
Friday, October 1, 2021
Unravelling the proteome: How we can use proteomics to understand and treat rare cancers
SEPTEMBER 30, 2021
by Diana Cano Bordajandi, Institute of Cancer Research

"Genomics' has become a buzzword in recent years, especially as it is increasingly used in the clinic. Proteomics, on the other hand, remains a bit of a mystery to many people.


Simply put, genomics is the study of the entire set of genes in a person, whereas proteomics is the study of the  ...more
Friday, October 1, 2021
Pancreatic cancer 'priming' may make chemotherapy more effective
SEPTEMBER 29, 2021
by Garvan Institute of Medical Research

A new approach to 'prime' the tumor environment may improve how effective chemotherapy is for pancreatic ductal adenocarcinoma, one of the most aggressive forms of pancreatic cancer.


In preclinical models, a team at the Garvan Institute of Medical Research could enhance the tumors' response to chemother  ...more
Friday, October 1, 2021
How high-fat diets allow cancer cells to go unnoticed
SEPTEMBER 28, 2021
by Cold Spring Harbor Laboratory

A high-fat diet increases the incidence of colorectal cancer. Cold Spring Harbor Laboratory Fellow Semir Beyaz and collaborators from Harvard Medical School and Massachusetts Institute of Technology have discovered that in mice, fat disrupts the relationship between intestinal cells and the immune cells that patrol  ...more
Friday, October 1, 2021
Some chemotherapy side effects caused by single mutation could be prevented
SEPTEMBER 27, 2021
by Will Doss, Northwestern University

Harmful side effects from a common chemotherapy drug could be the result of a single mutation, according to a study published in Cell Stem Cell.


The cardiotoxic effects of the chemotherapy drug doxorubicin could be prevented in patients with the mutation by treating them with retinoic acid, according to P  ...more
Friday, October 1, 2021
Breast cancer researchers learn how to teach an old drug new tricks to help patients
SEPTEMBER 24, 2021
Breast cancer researchers learn how to teach an old drug new tricks to help patients

by Chris Malina, University of Wisconsin-Madison
Beth Weaver wanted to know if there was a way to predict who would benefit from Taxol and who might not, to spare these patients the side effects of the potent chemotherapy drug. Credit: UW Carbone Cancer Center
...more
Friday, October 1, 2021
Eating spinach could protect against colon cancer
SEPTEMBER 23, 2021
by Lindsey Hendrix, Texas A&M University


A new study from the Texas A&M University Health Science Center (Texas A&M Health) suggests eating spinach could prevent colon cancer. And now, building on previous work, researchers are closer to understanding exactly how it works.


In the United States, colon cancer is the fourth-most common cancer   ...more
Friday, October 1, 2021
Study: Higher alcohol taxes could prevent thousands of cancers
SEPTEMBER 22, 2021
by Dresden University of Technology

Europe is the region with the highest per capita consumption of alcohol in the world. To reduce alcohol consumption and the associated health burden, increasing taxes on alcoholic beverages is a promising policy option. Alongside other measures, such as marketing bans for alcoholic beverages or reduced availabil  ...more
Thursday, August 19, 2021
First 3D-bioprinting of entire active tumor
AUGUST 18, 2021
by Tel-Aviv University


Microscopic image of the 3D-bioprinted glioblastoma model. The bioprinted blood vessels are covered with endothelial cells (red) and pericytes (cyan). The blood vessels are surrounded with a brain-mimicking tissue composed of gliblastoma cells (blue) and the brain microenvironment cells (green). Different drugs or cells can b  ...more
Thursday, August 19, 2021
New treatment method for breast cancer with less side effects
AUGUST 18, 2021
by Karolinska Institutet


Thomas Hatschek, associate professor at the department of Oncology-Pathology, together with colleagues, has recently published an article in JAMA Oncology showing that a new treatment for breast cancer with an antibody linked to a cytotoxic drug is as good as the previous combination, but with fewer side effects.

The dev  ...more
Thursday, August 19, 2021
Evolutionary forces affecting blood system aging could help identify people at increased risk of blood cancer
AUGUST 17, 2021
by Ontario Institute for Cancer Research

As people age, mutations can build up in blood stem cells and their clones in a process known as age-related clonal hematopoiesis, or ARCH. ARCH can be a risk factor for acute myeloid leukemia (AML), a form of blood cancer. New research provides insight into why some with ARCH go on to develop AML and others d  ...more
Thursday, August 19, 2021
Experimental drug that boosts immunotherapy shows promise in bladder cancer study
AUGUST 16, 2021
by UNC Lineberger Comprehensive Cancer Center

Experimental drug that boosts immunotherapy shows promise in bladder cancer study
http://www.scientificanimations.com/, CC BY-SA 4.0

A new study in mice found that adding the experimental drug entinostat to an immunotherapy-like treatment substantially boosted cancer remission. This approach shows suc  ...more
Thursday, August 19, 2021
Wearable temperature sensor provides early warning for complications in cancer patients
AUGUST 13, 2021
by University of Michigan

A simple, wearable temperature sensor was able to detect dangerous complications in hospitalized cancer patients hours earlier than routine monitoring, a team from the University of Michigan Rogel Cancer Center found.

The device, which takes readings every two minutes and wirelessly transmits them to the cloud, was able t  ...more
Thursday, August 19, 2021
New advances in treating non-small cell lung cancer
AUGUST 12, 2021
by Yale University


A new publication by Yale Cancer Center highlights recent breakthrough therapies developed to treat non-small cell lung cancer (NSCLC). The goal of the study is to provide views on how basic science advances will impact clinical research areas to help influence how NSCLC will be managed over the coming decade. The perspective is   ...more
Thursday, August 19, 2021
Analysis shows how a rare population of cancer cells contributes to disease relapse
AUGUST 11, 2021
by Allessandra Dicorato, Harvard Medical School


Most cancer-related deaths occur not from the first tumor to arise in a patient but from cancers that reappear months or years after treatment.

Scientists think that a group of rare cancer cells, called persister cells, might contribute to such recurrence. Persister cells account for only a fractio  ...more
Thursday, August 19, 2021
Hunting Down The Mutations That Cause Cancer Drug Resistance
AUGUST 10, 2021
Hunting down the mutations that cause cancer drug resistance
by UT Southwestern Medical Center

Using a virus to purposely mutate genes that produce cancer-driving proteins could shed light on the resistance that inevitably develops to cancer drugs that target them, a new study led by UT Southwestern scientists suggests. The findings, published onlin  ...more
Thursday, August 19, 2021
Cervical cancer rates stable or trending down in countries with effective screening measures
AUGUST 9, 2021
by Wiley

A recent trend analysis indicates that cervical cancer incidence and mortality rates have remained stable or are dropping in most countries across the globe. These rates differ based on each country's socioeconomic development level, cervical cancer screening use, and human papillomavirus (HPV) vaccination rates. The findings are published by  ...more
Thursday, August 19, 2021
Artificial Intelligence aids in discovery of new prognostic biomarkers for breast cancer
AUGUST 6, 2021
by Case Western Reserve University

Artificial Intelligence aids in discovery of new prognostic biomarkers for breast cancer
Images of the collagen network in breast tissue samples. Credit: Case Western Reserve University
Scientists at Case Western Reserve University have used Artificial Intelligence (AI) to identify new biomarkers for breast cancer   ...more
Thursday, August 19, 2021
Vitamin D reduces the need for opioids in palliative cancer
AUGUST 5, 2021
by Karolinska Institutet

Vitamin D reduces the need for opioids in palliative cancer

Main analysis: forest plots with beta coefficient and 95% CI over the opioid use in the ‘Palliative-D’ study. The intention-to-treat (ITT) analyses include all 244 randomized patients, and the Per Protocol (PP) analysis is based on the 150 patients that completed t  ...more
Wednesday, August 4, 2021
Frequent consumption of peanuts by cancer patients may increase risk of cancer spread
AUGUST 4, 2021
by University of Liverpool


A study by University of Liverpool researchers has identified new factors accompanying previous findings that frequent consumption of peanuts by cancer patients could increase risk of cancer spread.


The study, published in Carcinogenesis shows that Peanut agglutinin (PNA) – a carbohydrate-binding protein that rapidly   ...more
Wednesday, August 4, 2021
Statins may improve survival for triple-negative breast cancer patients
AUGUST 3, 2021
by University of Texas M. D. Anderson Cancer Center

A study led by researchers from The University of Texas MD Anderson Cancer Center found a significant association between cholesterol-lowering drugs commonly known as statins and survival rates of triple-negative breast cancer patients. Since statins are low in cost, easy to access and produce minima  ...more
Wednesday, August 4, 2021
Combined therapy shows promise for chronic lymphocytic leukemia
AUGUST 2, 2021
by Melissa Rohman, Northwestern University


A combination therapy pairing a small molecule inhibitor with monoclonal antibody immunotherapy improved patient outcomes for relapsed chronic lymphocytic leukemia (CLL), according to a Northwestern Medicine clinical trial published in Blood.


The findings support the practice of fixed-duration therapy   ...more
Wednesday, August 4, 2021
Pretreatment fatigue can mean worse survival outcomes for patients with cancer
JULY 30, 2021
by National Cancer Institute

Patients with cancer who reported clinically significant fatigue at the start of their treatment had shorter overall survival times and more side effects than patients without fatigue. Those are the findings of a new analysis of patients who took part in four clinical trials testing treatments for lung cancer or prostate ca  ...more
Wednesday, August 4, 2021
New cancer therapies that reduce the risk of heart damage
JULY 29, 2021
by Skylar Cuevas, Vanderbilt University

With modern-day cancer therapeutics presenting adverse side effects to heart health, scientists are studying methods to attack cancer cells without the risk of damaging the heart. Researchers Steven Townsend, associate professor of chemistry, and Neil Osheroff, John Coniglio Professor of Biochemistry and professo  ...more
Wednesday, August 4, 2021
Tiny bubbles used to treat common childhood cancer
JULY 28, 2021
by University College London


Researchers at UCL have developed a new way to deliver drugs that can shut down cancer-promoting mutations in neuroblastoma. The findings in mice, show the method, which uses tiny bubbles to deliver therapies directly to tumor cells, reduced tumor growth and improved survival.


Neuroblastoma is the most common solid t  ...more
Wednesday, August 4, 2021
Genomic test could help predict aggressive disease in men newly diagnosed with prostate cancer
JULY 27, 2021
by University of Michigan

After a biopsy comes back positive for prostate cancer, patients and their doctors are often left with a choice between taking a watch-and-wait approach, known as active surveillance, or proceeding with surgery or radiation.


And identifying which patients will benefit from more immediate and aggressive treatment isn't alw  ...more
Wednesday, August 4, 2021
New research identifies cancer types with little survival improvements in adolescents and young adults
JULY 26, 2021
by Wiley

Survival rates for adolescents and young adults diagnosed with cancer have varied considerably depending on cancer type. A new study indicates that survival for multiple cancer types in such patients has improved in recent years, but some patients diagnosed with common cancer types still show limited survival improvements. The results are publ  ...more
Thursday, May 13, 2021
argeting radiation resistance: Why some tumors are so stubborn
MAY 12, 2021
by Jerry Grillo, Georgia Institute of Technology

Radiation therapy has been—and will be—a cornerstone of cancer treatment for good reason: It works.

Mostly.

Currently, more than half of cancer patients receive radiation as part of their treatment. But 20 percent of them, give or take, will find that they need different options because their tumors  ...more
Thursday, May 13, 2021
New therapy shortens treatment for HPV-related cancers of the tonsils, tongue
MAY 11, 2021
by From Mayo Clinic News Network, Mayo Clinic News Network

Patients with HPV-related oropharyngeal cancer who undergo surgery and are treated with chemotherapy, may be able to forgo significant radiation therapy without increasing the risk of their cancer spreading, according to the results of a clinical trial led by researchers at Mayo Clinic.


"We  ...more
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